Butte Research Lab

Addressing fundamental and translational questions in immunology

The Butte lab has a clinical and research focus on immune diseases. We study inborn errors of immunity that contribute to infections, autoimmunity, immune dysregulation, inflammation, and cancer. We aim to improve the diagnosis, treatment, and cures of these diseases. 

Our main research work focuses on dysregulated immune responses to Valley fever causing life-threatening infections. We also have projects in vaccine development, metabolism, and mechanobiology (how cells make and sense mechanical forces). Many of these projects employ techniques from bioengineering, advanced microscopy, synthetic biology, and genetic sequencing. We believe that developing a stronger understanding of the fundamentals of the immune system improves our ability to treat autoimmunity, cancer, and infections.