Lab Overview

Basic Science

Our lab addresses fundamental and translational questions in immunology.

The fundamental focus of the lab is on human genetic immune diseases. These rare, inborn errors of immunity arise in children and adults and lead to infections, autoimmunity, immune dysregulation, inflammation, and cancer. We aim to improve the diagnosis, treatment, and cures of these diseases.

We also have projects in vaccine development, metabolism, and mechanobiology (how cells make and sense mechanical forces). Many of these projects employ techniques from bioengineering, advanced microscopy, synthetic biology, and genetic sequencing. We believe that developing a stronger understanding of the fundamentals of the immune system improves our ability to treat autoimmunity, cancer, and infections.


Rare Immune Diseases

Understanding the causes of primary immunodeficiencies

We believe that understanding the genetic, molecular, and cellular underpinnings of immune diseases offers the opportunity to develop targeted therapies. The lessons we learn from patients with primary immunodeficiencies extends our knowledge of the infections, autoimmune diseases, and cancers that affect all people.




Contact Us

Manish's Office

UCLA Department of Pediatrics
10833 Le Conte Ave
Marion Davies Children's Center (MDCC) Building, Room 12-430
Los Angeles, CA 90095
office: 310.825.0775
fax: 424.322.1923
metered parking: MDCC Parking Lot


Social Media




The Lab

The lab is located in the CHS Building, 4th floor, room 46-100.
metered parking: Parking Structure 18

 Mailing Packages to Lab:

Butte Lab @ UCLA
650 Charles E Young Dr South
CHS Building, Room 46-100
Los Angeles CA, 90095